Molecular mechanisms and pathogenesis of MASH

Gallage, S. #, Govaere, O., Anstee, Q.M., Shulman, G.I., Tacke, F., Heikenwalder, M. #

Current therapeutic landscape and future treatment perspectives of MASH

Gallage, S. #, Govaere, O., Anstee, Q.M., Shulman, G.I., Tacke, F. #, Heikenwalder, M. #

Single-nucleus profiling reveals hepatocyte identity and immune features associated with corticosteroid response in severe alcohol-related hepatitis

Van Melkebeke, L. #, Boesch, M., Ostyn, T., Huang, W., Akkaya, C., van Sligtenhorst, M., El Abyad, D., Safaeifard, F., Dumarey, A., Wallays, M., Boeckx, B., Feio-Azevedo, R., Smets, L., Gustot, T., Trepo, E., Moreno, C., Putignano, A., Lasser, L., Colle, I., Deltenre, P., Marot, A., Topal, B., Claus, E., Bonne, L., Maleux, G., Scheele, C., Hendrikx, T., Nevens, F., Korf, H., Roskams, T., Denadai-Souza, A., Lambrechts, D., Govaere, O., Van der Merwe, S. #, Verbeek, J. #

Integrated multi-omics identifies distinct macrophage alterations during progression of metabolic dysfunction-associated steatohepatitis

Boesch, M., Anak, S., El Abyad, D., Ostyn, T., Antoranz, A., My Van, T., Newhouse, D., Myers, C., Van Melkebeke, L., Palmer, J., Saffarzadeh, N., …, Schneider, K.M., Vacca, M., Allison, M., Ekstedt, M., Boursier, J., Bugianesi, E., Ratziu, V., De Smet, F., Boeckx, B., Daly, A.K., Schattenberg, J.M., Verbeek, J., Bosisio, F., Lambrechts, D., Roskams, T., Schneider, C.V., Francque, S., Korf, H., Hartlova, A., Tiniakos, D., Anstee, Q.M. #, van der Merwe, S. #, Govaere, O. #

Insulin-like Growth Factor-1 Reflects Liver Disease Stage and Improves Prediction of Liver-related Mortality

Schneider CV, Gross S, Balasubramani S, Tomanová P, Schrader C, Fromme M, Mandorfer M, Guldiken N, Schneider KM, Lurje G, Raptis A, Huang HYR, Mueller S, Reiberger T, Nahon P, Anstee QM, Daly AK, Govaere O, Strnad P. 

STAT1 drives the immune landscape of murine Toll-like receptor 9-induced liver inflammation

De Visscher, A., Beliën, J., Bernaerts, E., Vandeput, M., Malengier-Devlies, B., Prenen, F., Meers, H., Sokol, L., Mitera, T., Berghmans, N., Anak, S., Govaere, O., Van den Steen, P., Lamote, J., Vandamme, N., Bujko, A., Scott, C.L., Wouters, C. #, Matthys, P. #

Steatotic liver disease induces YAP/TAZ-driven cell competition that can suppress tumor initiation

Algueró-Nadal A, Mol H, Zoppolato E, Kowalczyk W, Sansores-García L, Soheily S, Hillen H, van Huffel L, Van Haele M, Corral-Ibáñez M, Hoffelner DK, van Grunsven LA, Roskams T, Govaere O, Moya IM, Halder G.

Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis

Del Zompo F, Crouchet E, Ostyn T, Nehme Z, Messé M, Juehling F, Désert R, Vieira AT, Moehlin J, Nakib D, Andrews T, Perciani C, …, Karlsen TH, Shankar G, Primeaux M, Dhawan P, Banales JM, Roehlen N, Iacone R, Teixeira G, Heikenwälder M, Mailly L, MacParland S, Roskams T, Govaere O, Schuster C, Baumert TF.

Adipose tissue macrophage dysfunction is associated with a breach of vascular integrity in NASH

Boesch M, Lindhorst A, Feio-Azevedo R, Brescia P, Silvestri A, Lannoo M, Deleus E, Jaekers J, Topal H, Topal B, Ostyn T, Wallays M, Smets L, Van Melkebeke L, Härtlova A, Roskams T, Bedossa P, Verbeek J, Govaere O, Francque S, Sifrim A, Voet T, Rescigno M, Gericke M, Korf H, van der Merwe S.

Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease

Armandi, A. #, Sanavia, T., Younes, R., Caviglia, G.P., Rosso, C., Govaere, O., …, Fracanzani, A.L., Valenti, L., Grieco, A., Miele, L., Fariselli, P., Eslam, M., Petta, S., Hagstroem, H., George, J., Schattenberg, J.M., Romero-Gomez, M., Anstee, Q.M., Bugianesi, E.

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

Vacca, M. #, Kamzolas, I., Harder, L.M., Oakley, F., Trautwein, C., Hatting, M., Ross, T., Bernardo, B., Oldenburger, A., Hjuler, S.T., …, Govaere, O., …, Bedossa, P., Stewart, M., Cater, H.L., Wells, S., Schattenberg, J.M., Anstee, Q.M., Tiniakos, D. #, Perfield, J.W. #, Petsalaki, E. #, Davidsen, P. #, Vidal-Puig, A. #

Pharmacogene expression during progression of metabolic dysfunction-associated steatotic liver disease: Studies on mRNA and protein levels and their relevance to drug treatment

Govaere, O., Cockell, S.J., Zatorska, M., Wonders, K., Tiniakos, D., Frey, A.M., Palmowksi, P., Walker, R., Porter, A., Trost, M., Anstee, Q.M., Daly, A.K.

A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures

Govaere, O., Hasoon, M., Alexander, L., Cockell, S., Tiniakos, D., Ekstedt, M., Schattenberg, J.M., Boursier, J., Bugianesi, E., Ratziu, V.K., LITMUS Investigators, Daly, A.K., Anstee, Q.M.

Sublethal necroptosis signaling promotes inflammation and liver cancer

Vucur, M. #, Ghallab, A., Schneider, A.T., Adili, A., Cheng, M., …, Govaere, O., …, Roderburg, C., Longerich, T., Weber, A., Villanueva, A., Samson, A.L., Murphy, J.M., Kramann, R., Geisler, F., Costa, I.G., Hengstle, J.G., Heikenwalder, M., Luedde, T. #

Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

Kotsiliti, E., Leone, V., Schuehle, S., Govaere, O., Li, H., Wolf, M.J., Horvatic, H., Bierwirth, S., Hundertmark, J., Inverso, D., Zizmare, L., Sarusi-Portuguez, A., Gupta, …, Macpherson, A., Knolle, P., Claassen, M., Geier, A., Trautwein, C., Unger, K., Elinav, E., Waisman, A., Abdullah, Z., Haller, D., Tacke, F., Anstee, Q.M., Heikenwalder, M.

Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease

Rosso, C., Caviglia, G.P., Birolo, G., Armandi, A., Pennisi, G., Pelusi, S., Younes, R., Liguori, A., Perez-Diaz-del-Campo, N., Nicolosi, A., Govaere, O., Castelnuovo, G., Olivero, A., Abate, M.L., Ribaldone, D.G., Fariselli, P., Valenti, L., Miele, L., Petta, S., Romero-Gomez, M., Anstee, Q.M., Bugianesi, E.

Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease

Govaere, O. #, Petersen, S.K., Martinez-Lopez, N., Wouters, J., Van Haele, M., Mancina, R.M., Jamialahmadi, O., Bilkei-Gorzo, O., Lassen, P.B., Darlay, R., Peltier, J., Palmer, J.M., Younes, R., Tiniakos, D., Aithal, G.P., Allison, M., Vacca, M., Goransson, M., Berlinguer-Palmini, R., Clark, J.E., Drinnan, M.J., Yki-Jarvinen, H., Dufour, J-F., Ekstedt, M., Francque, S., Petta, S., Bugianesi, E., Schattenberg, J.M., Day, C.P., Cordell, H.J., Topal, B., Clement, K., Romeo, S., Ratziu, V., Roskams, T., Daly, A.K., Anstee, Q.M. #, Trost, M. #, Hartlova, A. #

Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?

Younes, R., Govaere, O., Petta, S., Miele, L., Tiniakos, D., Burt, A., David, E., Vecchio, F.M., Maggioni, M., Cabibi, D., McLeod, D., Pareja, M.J., Fracanzani, A.L., Aller, R., Rosso, C., Ampuero, J., Gallego-Duran, R., Armandi, A., Caviglia, G.P., Zaki, M.Y W., Liguori, A., Francione, P., Pennisi, G., Grieco, A., Birolo, G., Fariselli, P., Eslam, M., Valenti, L., George, J., Romero-Gomez, M., Anstee, Q.M. #, Bugianesi, E. #

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Pfister, D., Nunez, N.G., Pinyol, R., Govaere, O., Pinter, M., Szydlowska, M., Gupta, R., Qiu, M., Deczkowska, A., Weiner, A., Muller, F., Sinha, A., Friebel, E., Engleitner, T., …, Ringelhan, M., Pinato, D.J., Rad, R., Mertens, J.C., Weber, A., Unger, K., Meissner, F., Roth, S., Jilkova, Z.M., Claassen, M., Anstee, Q.M., Amit, I., Knolle, P., Becher, B., Llovet, J.M. #, Heikenwalder, M. #

Transcriptomics Identify Thrombospondin-2 as a Biomarker for NASH and Advanced Liver Fibrosis

Kozumi, K., Kodama, T., Murai, H., Sakane, S., Govaere, O., Cockell, S., Motooka, D., Kakita, N., Yamada, Y., Kondo, Y., Tahata, Y., Yamada, R., Hikita, H., Sakamori, R., Kamada, Y., Daly, A.K., Anstee, Q.M., Tatsumi, T., Morii, E., Takehara, T.

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort

Anstee, Q.M. #, Darlay, R., Cockell, S., Meroni, M., Govaere, O., Tiniakos, D., Burt, A.D., Bedossa, P., Palmer, J., Liu, Y-L., Aithal, G.P., Allison, M., Yki-Jarvinen, H., Vacca, M., Dufour, J-F., Invernizzi, P., Prati, D., Ekstedt, M., Kechagias, S., Francque, S., Petta, S., Bugianesi, E., Clement, K., Ratziu, V., Schattenberg, J.M., Valenti, L., Day, C.P., Cordell, H.J., Daly, A.K. #

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Govaere, O., Cockell, S., Tiniakos, D., Queen, R., Younes, R., Vacca, M., Alexander, L., Ravaioli, F., Palmer, J., Petta, S., Boursier, J., Rosso, C., Johnson, K., Wonders, K., Day, C.P., Ekstedt, M., Oresic, M., Darlay, R., Cordell, H.J., Marra, F., Vidal-Puig, A., Bedossa, P., Schattenberg, J.M., Clement, K., Allison, M., Bugianesi, E., Ratziu, V., Daly, A.K. #, Anstee, Q.M. #